The researchers also found that babies of people who visited the ED or were hospitalized for cannabis use during pregnancy had very high rates of severe adverse outcomes, such as low birth weight, preterm birth, and admission to the neonatal intensive care unit (NICU).
“While these events—capturing very harmful patterns of cannabis use—are fortunately rare, we are concerned that they may reflect much larger increases in overall cannabis use in pregnant people following legalization,” says lead author and ICES Post-Doctoral Trainee Dr. Daniel Myran from the Department of Family Medicine at the Faculty of Medicine, who is also a family physician and Fellow at the Bruyère Research Institute and The Ottawa Hospital.
Published in CMAJ, the study included data for 980,398 pregnancies from 691,242 individuals between January 2015 and June 2021 in Ontario, Canada. Of the study population, 533 pregnant people had one or more pregnancies with an acute care visit (ED visit or hospitalization) for cannabis, with the majority of the events (72%) being ED visits. The most common reasons included harmful cannabis use (58%), cannabis dependence or withdrawal (22%) and cannabis poisoning (13%).
The researchers also found a significant link between treatment for severe morning sickness and treatment for cannabis use during pregnancy and noted that this relationship has grown even stronger since legalization.
“Severe morning sickness—or what is called 'hyperemesis gravidarum'—was frequently seen among individuals who received an acute care visit for cannabis use in pregnancy,” says senior author Dr. Andrea Simpson, adjunct scientist at ICES and an obstetrician and minimally invasive gynaecologic surgeon at St. Michael’s Hospital, a site of Unity Health Toronto. “Although we can’t say for sure whether they were presenting with vomiting as a result of cannabis use, or using cannabis to treat morning sickness, it does raise concern that more pregnant individuals perceive cannabis use in pregnancy to be less risky since legalization.”
The data showed that:
- Legalization was associated with a gradual increase over time in acute care visits for cannabis during pregnancy, which is consistent with increases in ED visits for cannabis use among the general population.
- Over the same time period there was no increase in acute care for other types of substance use (e.g. alcohol or opioids) during pregnancy and a decline in acute care for mental health conditions like depression and anxiety during pregnancy
- Compared to the general pregnant population, individuals visiting the ED or being hospitalized for cannabis use were younger (24 vs 30 years) and more likely to live in the lowest-income neighbourhoods (40% vs 22%) and rural settings (17% vs 9%).
- 32% of babies of pregnancies that received care for cannabis use were admitted to the NICU, 12% were in the smallest 5th percentile of birth weight, and 17% were born pre-term before 37 weeks gestation. After adjusting for key differences between the groups, pregnancies with acute care for cannabis continued to be associated twice the odds of these severe outcomes compared to pregnancies without.
This is an observational study, so cause and effect can’t be established. The researchers highlight that there could be other factors that are leading to the high risk of severe adverse outcomes in newborns in the study. Nevertheless, they say their findings add to the evidence of harm from cannabis use during pregnancy, and that people with heavy cannabis use could benefit from high-risk obstetrical care.
“There is a strong need for further interventions aimed at reducing cannabis use during pregnancy, including improved awareness of potential harms and screening for cannabis use” says Dr. Myran. “Our findings suggest that several higher risk groups, including individuals with severe morning sickness, may benefit from additional non-stigmatizing screening and counselling”.
The study, “Acute care due to cannabis during pregnancy after the legalization of non-medical cannabis in Ontario: a population-based, repeated cross-sectional study”, was published in CMAJ. Author block: Myran DT, Roberts R, Pugliese M, Corsi D, Walker M, El-Chaâr D, Tanuseputro P, Simpson A.
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