Biographie
Notice biographique
Le Dr Lisheng Wang est professeur au Département de biochimie, de microbiologie et d'immunologie de l'Université d'Ottawa, membre principal de l'Institut de biologie des systèmes d'Ottawa et chercheur affilié à l'Institut de recherche en santé d'Ottawa. Il est diplômé de l'école de médecine en Chine et a reçu sa formation clinique en tant que boursier de l'unité nationale australienne de transplantation hépatique. Le Dr Wang a obtenu un doctorat à l'Université de Sydney (Australie) où il a étudié l'immunologie de la transplantation. Il a ensuite poursuivi des recherches postdoctorales en immunologie à la Harvard Medical School, aux États-Unis, et d'autres recherches postdoctorales en biologie des cellules souches et en médecine régénérative à l'Institut de recherche Robarts, au Canada.
Intérêts de recherche
Le laboratoire du Dr Wang s'appuie sur des systèmes de modèles in vitro et in vivo pour élaborer des stratégies cellulaires, moléculaires et nanoparticulaires novatrices visant à faire progresser le traitement du cancer du sein. De plus, le laboratoire mène des recherches révolutionnaires en médecine régénérative, en utilisant les technologies des cellules souches pour réaliser des avancées transformatrices.
Pour de plus amples renseignements, veuillez communiquer avec le Dr Lisheng Wang au 613-562-5624 ou au [email protected]
Publications sélectionnées
- Annabelle Pfeifle, Wanyue Zhang, Jingxin Cao, Sathya Raman, Rose Anderson-Duvall, Levi Tamming, Caroline Gravel, Heather Coatsworth, Wangxue Chen, Michael Johnston, Simon Sauve, Michael Rosu-myles, Lisheng Wang & Xuguang Li. Novel recombinant vaccinia virus-vectored vaccine affords complete protection against homologous Borrelia burgdorferi infection in mice. Emerging Microbes & Infections2024; 13: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2399949
- F. St-Denis-Bissonnette, S. Qiu, S.E. Cummings, M. Kirkby, Y. Haile, S. Wassmer, G. Muradia, J. Mehic, A. Stalker, A. Shrestha, M. Ardolino, S.H. Lee, D. Burger, L. Wang & J.R. Lavoie. Evaluation of resazurin phenoxazine dye as a highly sensitive cell viability potency assay for natural killer cell-derived extracellular vesicle-based cancer biotherapeutics. Journal of Extracellular Biology. 2024; 3:e166. http://dx.doi.org/10.1002/jex2.166
- Karan Mediratta, Sara El-Sahli, Marie Marotel, Muhammad Z. Awan, Melanie Kirkby, Ammar Salkini, Reem Kurdieh, Salman Abdisalam, Amit Shrestha, Chiara Di Censo, Andrew Sulaiman, Sarah McGarry, Jessie R. Lavoie, Zhen Liu, Seung-Hwan Lee, Xuguang Li, Giuseppe Sciume, Vanessa M. D'Costa, Michele Ardolino@, Lisheng Wang@ (@corresponding authors).Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model. Frontiers in Immunology 2024;15https://doi.org/10.3389/fimmu.2024.1366197
- Shireesha Manturthi, Sara El-Sahli*, Yuxia Bo, Emma Durocher, Melanie Kirkby*, Alyanna Popatia*, Karan Mediratta*, Redaet Daniel, Seung-Hwan Lee, Umar Iqbal, Marceline Côté, Lisheng Wang @, Suresh Gadde@ (@corresponding authors). Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression in vitro and in vivo. ACS Nanoscience Au 2024; https://doi.org/10.1021/acsnanoscienceau.4c00040
- Frederic St-Denis-Bissonnette, Sarah E. Cummings, Shirley Qiu, Andrew Stalker, Gauri Muradia, Jelica Mehic, Karan Mediratta, Shelby Kaczmarek, Dylan Burger, Seung-Hwan Lee, Lisheng Wang@,Jessie R. Lavoie@ (@ corresponding authors). A clinically relevant large-scale biomanufacturing workflow to produce Natural Killer cells and Natural Killer cell-derived extracellular vesicles for cancer immunotherapy (Original Report). Journal of Extracellular Vesicles 2023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698709/The news appeared in GEN news in January 18, 2024 regarding Innovative Commercial NK-EV Production Process (genengnews.com)
- Lisheng Wang. Editorial for special issue “Cancer Treatment via Nanotherapy”. Nanomaterials 2023; 13: https://www.mdpi.com/2079-4991/13/7/1153
- Peixin Guan, Zhanchen Guo, Shuxin Xu, Haifeng Lu, Lisheng Wang, Zikuan Gu, Zhen Liu. Molecularly Imprinted Nanobeacons Redirect Innate Immune Killing towards Triple Negative Breast Cancer (Original Report). Angewandte Chemie-International Edition 2023; https://onlinelibrary.wiley.com/doi/10.1002/anie.202301202
- Abrar Ul Haq Khan, Alaa Kassim Ali, Bryan Marr, Donghyeon Jo, Simin Ahmadvand, Claire Fong-McMaster, Saeedah Musaed Almutairi, Lisheng Wang, Subash Sad, and Mary-Ellen Harper, Seung-Hwan Lee. The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis (Original Report). Cellular & Molecular Immunology. 2023;20:1140–1155 https://www.nature.com/articles/s41423-023-01071-4
- Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang & Zhen Liu. Molecularly imprinted polymer-based smart prodrug delivery system for specific targeting, prolonged retention and tumor microenvironment-triggered release (Original Report). Angewandte Chemie-International Edition2021;60:2663-2667. https://doi.org/10.1002/anie.202012956
- Sara El-Sahli, Khang Hua, Andrew Sulaiman, Jason Chambersa, Li Li, Elijah Farah, Dan Liu, Sarah McGarry, Peiyong Zheng, Seung-Hwan Lee, Jiefeng Cui, Marc Ekker, Marceline Cote, Tommy Alain, Xuguang Li, Vanessa D’Costa, Lisheng Wang@ and Suresh Gadde@ (@corresponding author). A triple-drug nanotherapy to target breast cancer cells, cancer stem cells and tumor vasculature (Original Report). Cell Death & Disease2020;12: 8.https://doi.org/10.1038/s41419-020-03308-w
- Shuxin Xu, Lisheng Wang & Zhen Liu. Molecularly Imprinted Polymer Nanoparticles: An Emerging Versatile Platform for Cancer Nanomedicine (Review). Angewandte Chemie- International Edition 2020. https://onlinelibrary.wiley.com/doi/10.1002/anie.202005309
- Shrey Sindhwani#, Abdullah Muhammad Syed# (#equal contribution), Jessica Ngai, Benjamin R. Kingston, Laura Maiorino, Jeremy Rothschild, Presley MacMillan, Yuwei Zhang, Netra Unni, Tran Hoang, Stefan Wilhelm, Anton Zilman, Suresh Gadde, Andrew Sulaiman, Ben Ouyang, Zachary Lin, Lisheng Wang, Mikala Egeblad, Warren C. W. Chan.The entry of nanoparticles into solid tumors Nature MaterialsNature Materials 2020; 19: 566-579.