Validation de l’applicabilité d’outils exhaustifs de biologie moléculaire, comme la génomique (transcriptomique, protéomique, sécrétomique et métabonomique), visant la détermination des dangers, le calcul du risque et la surveillance réglementaire qui en découle, relativement au risque d’exposition humaine à des substances chimiques présentes dans l’environnement, notamment les nanomatériaux artificiels.
Publications sélectionnées
- Sarah Labib, Charles H Guo, Andrew Williams, Carole L Yauk, Paul A White, Sabina Halappanavar*. Toxicogenomic outcomes predictive of forestomach carcinogenesis following exposure to benzo(a)pyrene: relevance to human cancer risk. Toxicology and Applied Pharmacology, in press, 2013
- Husain M, Saber AT, Guo C, Jacobsen NR, Jensen KA, Yauk CL, Williams A, Vogel U, Wallin H, Halappanavar S*. Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation. Toxicolology and Applied Pharmacology Jun 15;269(3):250-62, 2013
- Andrea Rowan-Carroll A, Halappanavar S*, Williams A, Somers CM, Yauk CL.. Mice exposed in situ to urban air pollution exhibit pulmonary alterations in gene expression in the lipid droplet synthesis pathways. Environ Mol Mutagen. May;54(4):240-9, 2013
- Happanavar S*, Nikota J, Wu D, Williams A, Yauk CL, Stampfli M.. IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation. J Immunol. 2013 Apr 1;190(7):3679-86, 2013
- Jackson P, Halappanavar S, Hougaard KS, Williams A, Madsen AM, Lamson JS, Andersen O, Yauk C, Wallin H, Vogel U.. Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: effects in prenatally exposed offspring on hepatic DNA damage and gene expression. Nanotoxicology. 2013 Feb;7(1):85-96, 2013