David A. Landry

Appointed in September 2022, David Landry is an assistant professor focused on the developmental origins of health and disease. He has training as a reproductive biologist specializing in both female and male reproductive health. During his postdoctoral research, Professor Landry examined the origins and characteristics of ovarian fibrosis and its association with the risk of ovarian cancer. He also identified the crucial role of chromatin remodelling complexes in female fertility.

Professor Landry received his PhD at Université Laval. His doctoral studies centred around characterizing cell signalling in ovarian follicle cells in relation to oocyte quality and developing innovative strategies and tools to optimize egg quality, in collaboration with the Canadian cattle industry. During his MSc at the Université de Moncton, he investigated the effects of obesity-related hormones on male reproduction.

David Landry comes from a New Brunswick family with deep agricultural roots. He is Acadian and a member of the Pekuakamiulnuatsh Takuhikan First Nation.

Professor Landry is accepting new students for thesis supervision.

• Female reproductive health: steroidogenesis, oocyte quality and follicle development
• Ovarian aging: origin and treatment for ovarian fibrosis
• Reproductive cancer: prevention and treatments
• DOHaD: polycystic ovary syndrome, epigenetics and hyperandrogenism
• Cannabinoids: female reproduction, epigenetics and oocyte quality

The Reproduction, Endocrinology, and Cancer (REC) Research Laboratory, led by Professor Landry, focuses on female reproductive health and healthy aging.

Recent studies have linked ovarian aging to the accumulation of ovarian fibrosis. The lab’s research aims to understand the origins of this process and explore strategies for its prevention and reversal. There is also a possible association of this phenomenon with a higher risk of ovarian cancer, and the lab is working to develop new therapeutic approaches to prevent ovarian cancer in aging women.

Additionally, the lab is investigating the effects of cannabis on female reproductive health. Since its legalization, cannabis is being used by approximately 19% of Canadians of reproductive age. However, research on its impact on female reproduction, steroid production and gamete quality remains limited.

The lab is also exploring the potential therapeutic role of medical cannabis in treating conditions such as polycystic ovary syndrome (PCOS) and reproductive cancers.

• Landry, D. A., Yakubovitch E., Cook D.P., Fasih S., Upham J., Vanderhyden B. C. (2022). “Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice.” Science Advances, 2;8(35).
• Landry, D. A., Abedini A., Macaulay A., Vaishnev H., Parbhakar A., Salehi R., Maranda V., Macdonald E., Vanderhyden B. C. (2022). “SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility.” (Submitted, in Revision).
• Carter, L.E., Cook, D.P., McCloskey, C.W., Grondin, M.A., Landry, D.A., Dang, T., Collins, O., Gamwell, L.F., Dempster, H.A., Vanderhyden’ B.C. (2021). Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium. Communications Biology, 4(1), 1-11.
• Landry, D. A., Vaishnav, H. T., & Vanderhyden, B. C. (2020). The significance of ovarian fibrosis. Oncotarget, 11(47), 4366.
• Mehdi, S., Macdonald, E., Galpin, K., Landry, D. A., Rodriguez, G., Vanderhyden, B., & Bachvarov, D. (2020). LY75 Suppression in Mesenchymal Epithelial Ovarian Cancer Cells Generates a Stable Hybrid EOC Cellular Phenotype, Associated with Enhanced Tumor Initiation, Spreading and Resistance to Treatment in Orthotopic Xenograft Mouse Model. International Journal of Molecular Sciences, 21(14), 4992.
• Landry, D. A., Rossi-Perazza, L., Lafontaine, S., & Sirard, M. A. (2018). Expression of atresia biomarkers in granulosa cells after ovarian stimulation in heifers. Reproduction, 156(3), 239-248.
• Landry, D. A., & Sirard, M. A. (2018). Follicle capacitation: A meta-analysis to investigate the transcriptome dynamics following FSH decline in bovine granulosa cells. Biology of reproduction, 99(4), 877-887.
• Landry, D. A., Labrecque, R., Grand, F. X., Vigneault, C., Blondin, P., & Sirard, M. A. (2018). Effect of heifer age on the granulosa cell transcriptome after ovarian stimulation. Reproduction, Fertility and Development, 30(7), 980-990.
• Landry, D. A., Fortin, C., Bellefleur, A. M., Labrecque, R., Grand, F. X., Vigneault, C., … & Sirard, M. A. (2017). Comparative analysis of granulosa cell gene expression in association with oocyte competence in FSH-stimulated Holstein cows. Reproduction, Fertility and Development, 29(12), 2324-2335.
• Landry, D. A., Sormany, F., Haché, J., Roumaud, P., & Martin, L. J. (2017). Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells. Molecular and Cellular Biochemistry, 433(1-2), 79-95.
• Khan, D. R., Landry, D. A., Fournier, É., Vigneault, C., Blondin, P., & Sirard, M. A. (2016). Transcriptome meta-analysis of three follicular compartments and its correlation with ovarian follicle maturity and oocyte developmental competence in cows. Physiological Genomics, 48(8), 633-643.
• Landry D. A., Bellefleur A-M, Labrecque R, Grand F-X, Vigneault C, Blondin P and Sirard M-A (2016) Effect of cow age on the in vitro developmental competence of oocytes obtained after FSH stimulation and coasting treatments. Theriogenology, 1240-1246.
• Landry, D., Paré, A., Jean S., Martin, L.J. (2014) Adiponectin influences progesterone production from MA-10 Leydig Cells in a dose-dependent manner. Endocrine 48.3 (2015) : 957-967.
• Landry, D., Cloutier,F., et Martin, L.J. (2013) Implications of leptin in neuroendocrine regulation of male reproduction. Reproductive Biology, 13(1) :1-14.
• Jean, S., Landry, D., Daigle, M. et Martin, L.J. (2012) Influence of the adipose derived hormone resistin on STAT factors, steroidogenesis and proliferation of Leydig cells. Asian Pacific Journal of Reproduction, 1(1) :1-6.