David A. Landry

Dr. Landry’s research as a principal investigator focuses on the developmental origins of health and diseases (DOHaD). He seeks to understanding how the hostile endocrine environment of the polycystic ovary syndrome (PCOS) in mothers may promote aberrant epigenetic reprogramming leading to physiological changes in the fetus and the emergence of PCOS and obesity during adulthood. He is investigating the impact of hormonal and metabolic disturbance during the windows of susceptibility (pre-conception, at conception or in utero) across generations.

Dr. Landry’s postdoctoral research project focused on the origin and characterization of ovarian fibrosis and the risk of developing ovarian cancer. He also aims to identify the role of chromatin remodelling complexes in female fertility.

Dr. Landry received his PhD at the Centre de recherche en reproduction, développement et santé intergénérationnelle at Université Laval. During his doctoral studies, he characterized cell signalling in ovarian follicle cells in association with oocyte quality and developed new strategies and tools for optimizing egg quality, in collaboration with the Canadian cattle industry. During his BSc and his MSc at the Université de Moncton, he studied the effects of obesity-related hormones on male reproductive capacity.

Dr. Landry is a member of the Pekuakamiulnuatsh First Nation community of Mashteuiatsh and a francophone Acadian from New Brunswick. 

Dr. Landry is accepting new students for thesis supervision.

• Female fertility: steroidogenesis, oocyte quality and follicle development
• DOHaD: polycystic ovary syndrome, epigenetics and hyperandrogenism
• Cannabinoids: female reproduction, epigenetics and oocyte quality
• Ovarian aging: ovarian fibrosis, epi-mutation and fibroblasts
• Cancer: extracellular matrix modulation and CAF

Landry, D. A., Yakubovitch E., Cook D.P., Fasih S., Upham J., Vanderhyden B. C. (2022). “Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice.” Science Advances, 2;8(35).

Landry, D. A., Abedini A., Macaulay A., Vaishnev H., Parbhakar A., Salehi R., Maranda V., Macdonald E., Vanderhyden B. C. (2022). “SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility.” (Submitted, in Revision)

Carter, L.E., Cook, D.P., McCloskey, C.W., Grondin, M.A., Landry, D.A., Dang, T., Collins, O., Gamwell, L.F., Dempster, H.A., Vanderhyden’ B.C. (2021). Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium. Communications Biology, 4(1), 1-11.

Landry, D. A., Vaishnav, H. T., & Vanderhyden, B. C. (2020). The significance of ovarian fibrosis. Oncotarget, 11(47), 4366.

Mehdi, S., Macdonald, E., Galpin, K., Landry, D. A., Rodriguez, G., Vanderhyden, B., & Bachvarov, D. (2020). LY75 Suppression in Mesenchymal Epithelial Ovarian Cancer Cells Generates a Stable Hybrid EOC Cellular Phenotype, Associated with Enhanced Tumor Initiation, Spreading and Resistance to Treatment in Orthotopic Xenograft Mouse Model. International Journal of Molecular Sciences, 21(14), 4992.

Landry, D. A., Rossi-Perazza, L., Lafontaine, S., & Sirard, M. A. (2018). Expression of atresia biomarkers in granulosa cells after ovarian stimulation in heifers. Reproduction, 156(3), 239-248.

Landry, D. A., & Sirard, M. A. (2018). Follicle capacitation: A meta-analysis to investigate the transcriptome dynamics following FSH decline in bovine granulosa cells. Biology of reproduction, 99(4), 877-887.

Landry, D. A., Labrecque, R., Grand, F. X., Vigneault, C., Blondin, P., & Sirard, M. A. (2018). Effect of heifer age on the granulosa cell transcriptome after ovarian stimulation. Reproduction, Fertility and Development, 30(7), 980-990.

Landry, D. A., Fortin, C., Bellefleur, A. M., Labrecque, R., Grand, F. X., Vigneault, C., … & Sirard, M. A. (2017). Comparative analysis of granulosa cell gene expression in association with oocyte competence in FSH-stimulated Holstein cows. Reproduction, Fertility and Development, 29(12), 2324-2335.

Landry, D. A., Sormany, F., Haché, J., Roumaud, P., & Martin, L. J. (2017). Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells. Molecular and Cellular Biochemistry, 433(1-2), 79-95.

Khan, D. R., Landry, D. A., Fournier, É., Vigneault, C., Blondin, P., & Sirard, M. A. (2016). Transcriptome meta-analysis of three follicular compartments and its correlation with ovarian follicle maturity and oocyte developmental competence in cows. Physiological Genomics, 48(8), 633-643.

Landry D. A., Bellefleur A-M, Labrecque R, Grand F-X, Vigneault C, Blondin P and Sirard M-A (2016) Effect of cow age on the in vitro developmental competence of oocytes obtained after FSH stimulation and coasting treatments. Theriogenology, 1240-1246.

Landry, D., Paré, A., Jean S., Martin, L.J. (2014) Adiponectin influences progesterone production from MA-10 Leydig Cells in a dose-dependent manner. Endocrine 48.3 (2015) : 957-967.

Landry, D., Cloutier,F., et Martin, L.J. (2013) Implications of leptin in neuroendocrine regulation of male reproduction. Reproductive Biology, 13(1) :1-14.

Jean, S., Landry, D., Daigle, M. et Martin, L.J. (2012) Influence of the adipose derived hormone resistin on STAT factors, steroidogenesis and proliferation of Leydig cells. Asian Pacific Journal of Reproduction, 1(1) :1-6.