Dr. Consolato M. Sergi

Dr. Consolato M. Sergi

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Dr. Consolato M. Sergi
Chief, Anatomic Pathology Division, Children's Hospital of Eastern Ontario


Phone
613-737-7600 ext. 2427


Biography

Consolato M. Sergi is the Chief of the Anatomic Pathology Division at the Children’s Hospital of Eastern Ontario, Professor of Pediatrics and Pathology, University of Alberta and Ottawa, Canada. Dr. Sergi is Canadian, born in Rome (Italy), obtained his MD degree with honors, qualification in Pediatrics, and Pediatric Pathology Fellowship at the University of Genoa, Italy. Dr. Sergi obtained his qualification in Pathology at the Ruprecht Karl University of Heidelberg, Germany, the Clinical Reader title at the University of Bristol, UK, PhD/Habilitation at the University of Innsbruck, Austria, MPH in Austria, and FRCPC (Pathology) from the Royal College of Physicians and Surgeons of Canada. In his research, he established his Canadian laboratory in August 2008. He welcomed more than 100 graduate MSc/Ph.D. students, fellows, undergraduate and summer students with on-going teaching in Genetics and Pathology. Dr. Sergi is a Consultant of Carcinogenesis in Experimental Animals at the WHO/IARC, Lyon, France, and an “ad-hoc” Peer-Referee for the National Toxicology Program, NIH, USA. His areas of interest are Biology and Pathology of the Cardiovascular/Gastrointestinal System and Gut/Bile Microbiome as well as Bone Cell Biology. Dr. Sergi has >300 peer-reviewed PubMed publications (h-index: 23, RG-score: 44.26, > 2,500 citations). He identified the role of apoptosis in the ductal plate malformation of the liver (Am J Pathol, 2000), a new CTL4/Neu1 gene fusion transcript in sialidosis (Hum Genet 2001, FEBS Lett 2002, J Med Genet 2003), two new genes, i.e., WDR62, which encodes a centrosome-associated protein (Nat Genet 2010) and OTX2, mutations of which contribute to dysgnathia (J Med Genet 2012), as well as characteristics of the bile microbiome (Infect Drug Resist 2019, HPB (Oxford) 2019, J Med Microbiol 2018, Eur J Clin Microbiol Infect Dis, 2018). He is editor in chief and in the editorial board of prestigious medical journals and international agencies.

Publications:

  • Sergi CM. Pediatric sarcoidosis with diagnostic and therapeutical insights. Curr Opin Pulm Med. 2021 Sep 1;27(5):472-477. doi: 10.1097/MCP.0000000000000814. PMID: 34397614.
  • Sergi CM. Targeting the 'garbage-bin' to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU. Biosci Rep. 2021 Aug 27;41(8):BSR20210952. doi: 10.1042/BSR20210952. PMID: 34323266; PMCID: PMC8350430.
  • Sergi CM, Leung AKC. Vaccination: a question of social responsibility. J Prev Med Hyg. 2021 Apr 29;62(1):E46-E47. doi: 10.15167/2421-4248/jpmh2021.62.1.1736. PMID: 34322615; PMCID: PMC8283621.
  • Khattak A, Kanwar B, Sergi C, Lee CJ, Balentine J, Lee JH, Park J, Lee SJ, Choi SH. Commentary for the Elderly in the Pandemic Era. Dement Geriatr Cogn Dis Extra. 2021 Jun 10;11(2):168-171. doi: 10.1159/000515926. PMID: 34249073; PMCID: PMC8255700.
  • Serra N, Di Carlo P, Rea T, Sergi CM. Diffusion modeling of COVID-19 under lockdown. Phys Fluids (1994). 2021 Apr;33(4):041903. doi: 10.1063/5.0044061. Epub 2021 Apr 12. PMID: 33897246; PMCID: PMC8060971.
  • Leung AKC, Sergi CM, Leong KF, Kantor PF, Md. Visual Diagnosis: High Fever, Maculopapular Rash, Perianal Desquamation, and Conjunctivitis in a 3-year-old Boy. Pediatr Rev. 2021 May;42(5):e17-e22. doi: 10.1542/pir.2018-0330. PMID: 33931516.
  • Lu HY, Sharma M, Sharma AA, Lacson A, Szpurko A, Luider J, Dharmani-Khan P, Shameli A, Bell PA, Guilcher GMT, Lewis VA, Vasquez MR, Desai S, McGonigle L, Murguia-Favela L, Wright NAM, Sergi C, Wine E, Overall CM, Suresh S, Turvey SE. Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency. J Allergy Clin Immunol. 2021 Apr 17:S0091-6749(21)00612-6. doi: 10.1016/j.jaci.2021.04.006. Epub ahead of print. PMID: 33872653.
  • Hatami S, Qi X, White CW, Bozso SJ, Himmat S, Sergi C, Nagendran J, Chung HJ, Nobes DS, Freed DH. The Position of the Heart During Normothermic Ex Situ Heart Perfusion is an Important Factor in Preservation and Recovery of Myocardial Function. ASAIO J. 2021 Mar 17. doi: 10.1097/MAT.0000000000001386. Epub ahead of print. PMID: 33741785.
  • Khan A, Das S, Sergi C. Therapeutic Potential of Neu1 in Alzheimer's Disease Via the Immune System. Am J Alzheimers Dis Other Demen. 2021 Jan- Dec;36:1533317521996147. doi: 10.1177/1533317521996147. PMID: 33719595.
  • Wu HH, Wang B, Armstrong SR, Abuetabh Y, Leng S, Roa WHY, Atfi A, Marchese A, Wilson B, Sergi C, Flores ER, Eisenstat DD, Leng RP. Hsp70 acts as a fine- switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation. Nucleic Acids Res. 2021 Mar 18;49(5):2740-2758. doi: 10.1093/nar/gkab081. PMID: 33619536; PMCID: PMC7969027.
  • Abou Zeinab R, Wu HH, Abuetabh Y, Leng S, Sergi C, Eisenstat DD, Leng RP. Pirh2, an E3 ligase, regulates the AIP4-p73 regulatory pathway by modulating AIP4 expression and ubiquitination. Carcinogenesis. 2021 Apr 30;42(4):650-662. doi: 10.1093/carcin/bgab009. PMID: 33569599; PMCID: PMC8086772.
  • Serra N, Di Carlo P, D'Arpa F, Battaglia E, Fasciana T, Gulotta G, Maida CM, Rodolico V, Giammanco A, Sergi C. Human bile microbiota: A retrospective study focusing on age and gender. J Infect Public Health. 2021 Feb;14(2):206-213. doi: 10.1016/j.jiph.2020.11.005. Epub 2021 Jan 22. PMID: 33486377.
  • Sergi C, Villanacci V, Carroccio A. Non-celiac wheat sensitivity: rationality and irrationality of a gluten-free diet in individuals affected with non-celiac disease: a review. BMC Gastroenterol. 2021 Jan 6;21(1):5. doi: 10.1186/s12876-020-01568-6. PMID: 33407153; PMCID: PMC7788993.
  • Sergi CM. Lupus nephritis and Zimmerhackl's legacy for histopathology: A milestone for clinical trials and reduction of interobserver disagreement. Lupus. 2021 Mar;30(3):534-536. doi: 10.1177/0961203320983916. Epub 2021 Jan 6. PMID: 33407047.
  • Zhang H, Viveiros A, Nikhanj A, Nguyen Q, Wang K, Wang W, Freed DH, Mullen JC, MacArthur R, Kim DH, Tymchak W, Sergi CM, Kassiri Z, Wang S, Oudit GY. The Human Explanted Heart Program: A translational bridge for cardiovascular medicine. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165995. doi: 10.1016/j.bbadis.2020.165995. Epub 2020 Oct 22. PMID: 33141063; PMCID: PMC7581399.
  • Jantuan E, Chiu B, Chiu B, Shen F, Oudit GY, Sergi C. The tumor microenvironment may trigger lymphoproliferation in cardiac myxoma. Transl Oncol. 2021 Jan;14(1):100911. doi: 10.1016/j.tranon.2020.100911. Epub 2020 Oct 23. PMID: 33129111; PMCID: PMC7586245.

Books:

  • Sergi CM. Pathology of Childhood and Adolescence - An Illustrated Guide, Publisher: Springer Nature
  • Sergi CM, editor. Liver Cancer [Internet]. Brisbane (AU): Exon Publications; 2021 Apr 6.

Books Chapters:

  • Sergi C, Parayil Sankaran B. Succinic Semialdehyde Dehydrogenase Deficiency. 2021 Aug 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32809559.
  • Sergi C, Davis DD. Incident Reporting. 2021 Jul 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32809333.
  • Riaz Y, Sergi C. Feeding Disability In Children. 2021 Jul 18. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 33231976.
  • Shen F, Sergi C. Biochemistry, Amino Acid Synthesis and Degradation. 2021 May 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32644676.
  • Lachance E, Mandziuk J, Sergi CM, Bateman J, Low G. Radiologic-Pathologic Correlation of Liver Tumors. In: Sergi CM, editor. Liver Cancer [Internet]. Brisbane (AU): Exon Publications; 2021 Apr 6. Chapter 5. PMID: 33905200.
  • Beach M, Caviedes LH, Sergi CM. Gross Dissection of Liver for Hepatocellular Carcinoma Using AJCC Cancer Staging Manual 8th Edition: Anatomical and Practical Considerations. In: Sergi CM, editor. Liver Cancer [Internet]. Brisbane (AU): Exon Publications; 2021 Apr 6. Chapter 4. PMID: 33905199.
  • Sergi CM. Carcinoma of the Liver in Children and Adolescents. In: Sergi CM, editor. Liver Cancer [Internet]. Brisbane (AU): Exon Publications; 2021 Apr 6. Chapter 1. PMID: 33905198.
  • Hager J, Sergi CM. Hepatoblastoma. In: Sergi CM, editor. Liver Cancer [Internet]. Brisbane (AU): Exon Publications; 2021 Apr 6. Chapter 8. PMID: 33905194.