Dr. Harpal S. Buttar

Dr. Harpal S. Buttar
Dr. Harpal S. Buttar
Senior Scientist, Reproduction and Urology Division, Therapeutic Products
Directorate, Health Canada
Adjunct Professor, Department of Pathology and Laboratory Medicine, Faculty of Medicine.


Phone
613-824-1532

Personal Email: [email protected]

Biography

Recent Publications

  • Sakshi M. Kothawade, Harpal Singh Buttar, Hardeep Singh Tuli, Ginpreet Kaur (2023): Therapeutic potential of flavonoids in the management of obesity‑induced Alzheimer’s disease: an overview of preclinical and clinical studies.Naunyn-Schmiedeberg's Archives of Pharmacology, Published online: 25 May 2023, pages 1-18. DOI: https://doi.org/10.1007/s00210-023-02529-y
  • Istvan G. Télessy, Harpal S. Buttar, Douglas W. Wilson, Charles Odilichukwu R. Okpala (2023): Dietary supplements could prevent cardiometabolic syndrome: Are they safe and reliable enough for disease prevention and health promotion? Front. Cardiovasc. Med., Sec. General Cardiovascular Medicine. Volume 10, pages 1-7. DOI:| https://doi.org/10.3389/fcvm.2023.1091327
  • Junit K. Mehta, Ginpreet Kaur, Harpal S. Buttar, Hala Abubaker Bagabir, Rania Abubaker Bagabir, Sali Abubaker Bagabir, Shafiul Haque, Hardeep S. Tuli, Istvan G. Telessy (2023): Role of the renin–angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products. Front. Physiol., Sec. Vascular Physiology, Volume 14, pages 1-11. DOI:  https://doi.org/10.3389/fphys.2023.1034170
  • Vinay Chaudhari, Siddhi Bagwe‑Parab, Harpal S. Buttar, Shubhangi Gupta, Amisha Vora, Ginpreet Kaur (2023): Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload‑Induced Alzheimer’s Disease. Neurotoxicity Research. Published Online: 27 January 2023, pages 1-18.DOI: https://doi.org/10.1007/s12640-023-00634-7
  • Dziewiecka, H., Buttar, H.S., Kasperska, A., Ostapiuk–Karolczuk, J., Domagalska, M., Cichoń, J. and Skarpańska‑Stejnborn, A. (2022): Physical activity induced alterations of gut microbiota in humans: a systematic review. BMC Sports Science, Medicine and Rehabilitation 14:122, pp. 1-22. https://doi.org/10.1186/s13102-022-00513-2
  • Singh, R.B., Juneja, L., Wilson, D.W., De Meester, F., Wilczynska, A., Takahashi, T. Watanabe, S., Buttar, H.S., Fatima, G., Mahashwari, A., Verma, N., et al. (2022):  Diet and Lifestyle Guidelines for Immunomodulation with Reference to Corona Virus Pandemic: A Scientific Statement of the International College of Nutrition. World Heart Journal, 13 (4), 499-517
  • Davinder Singh,  Prabhjot Kaur,  Shivani Attri, Sharabjit Singh,  Palvi Sharma, Pallavi Mohana, Kirandeep Kaur, Harneetpal Kaur, Gurdeep Singh, Farhana Rashid , Dilpreet Singh, Avinash Kumar, Ankita Rajput, Neena Bedi, Balbir Singh, Harpal Singh Buttar and Saroj Arora (2022): Recent Advances in the Local Delivery Systems for Improvement of Anticancer Therapy. Current Drug Delivery, 19 (5), 22 April, 2022, pp. 560-586. DOI: 10.2174/1567201818666211214112710
  • Mehra R, Garhwal R, Sangwanm K, Guiné RPF, Lemos ET, Buttar HS, Visen PKS, Kumar N, Bhardwaj A and Kumar H (2022): Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements. Nutrients, 2022,14,1-21 659 https://doi.org/10.3390/nu14030659
  • Mehra R, Kumar H, Kumar N, Ranvir S, Jana A, Buttar HS, Telessy IG, Awuchi CG, Okpala COR, Korzeniowska M, Guine RPF (2021): Whey proteins processing and emergent derivatives: An insight perspective from constituents, bioactivities functionalities to therapeutic applications. J. Functional Foods 87,104760. pp 1- 17. https:// doi.org/10.1016/j.jff.2021.104760
  • Hussein L, Gouda M and Buttar HS (2021): Pomegranate, its components, and modern deliverable formulations as potential botanicals in the prevention and     treatment of various cancers. Current Drug Delivery Journal. Vol.18, 1-15. DOI:10.2174/156720181866621020
  • Bichitra N. Nayak, B.N., Singh R. B. and Buttar , H.S. (2019): Role of Tryptophan in Health and Disease: Systematic Review of the Anti-Oxidant, Anti-Inflammation, and Nutritional Aspects of Tryptophan and Its Metabolites. World Heart Journal, 11 (2), 161 – 178.
  • Bagwe-Parab, S., Yadav, P., Kaur, G., Tuli, H.S. and  Buttar, H.S. (2020): Therapeutic applications of human and bovine colostrum in the treatment of gastrointestinal diseases and distinctive cancer types: The current evidence. Front. Pharmacol. Vol. 11 (01100), 1-12. doi: 10.3389/fphar.2020.01100Vol. 74 (104119), pages 1-10.
  • Mehra R, Singh R, Nayan V, Buttar HS , Kumar N, Shiv K, BhardwaA, Kaushik R and Kumar H (2021): Nutritional attributes of bovine colostrum components in human health and disease: A comprehensive review, Food Bioscience, Vol. 40: 100907, pages 1-15.
  • Tuli HS, Aggarwal V,  Parashar G, Aggarwal D, Nidarshana C. Parashar NC, Tuorkey MJ, Sak K, Kumar M,  Buttar HS (2021): Xanthohumol: A metabolite with promising anti-neoplastic potential. Anti-Cancer Agents in Medicinal Chemistry. Vol. 21, Issue 18, Online ahead of print. DOI : 10.2174/1871520621666210223095021
  • Galdino  ABS, Rangel AHN, Buttar HS, Nascimento MSL, Gavioli EC, Oliveira RP, Sales DC, Urbano SA, Anaya K (2021): Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical managemet of COVID-19. Food and Agricultural Immunology, 32 (1):143-162, DOI: 10.1080/09540105.2021.1892594
  • Hussein L, Gouda M and Buttar HS (2021): Pomegranate, its components, and modern deliverable formulations as potential botanicals in the prevention and treatment of various cancers. Current Drug Delivery Journal. Vol.18, 1-15. DOI:10.2174/156720181866621020

Book Chapters

  • Jessica Rajesh Dmello, Lakshmi Parag Chandekar, Tanya Ashit Bavadekar, Harpal S. Buttar, and Ginpreet Kaur (2023): Quercetin: A Promising Flavonoid for the Therapy of Cardiac Hypertrophy and Heart Failure Mediated by the Renin Angiotensin System. In: The Renin Angiotensin System in Cardiovascular Disease. Advances in Biochemistry in Health and Disease 24. Published by Springer. (Editors: Naranjan S. Dhalla, Sukhwinder K. Bhullar and Anureet K. Shah). Chapter 23, pages 377- 405. DOI: https://doi.org/10.1007/978-3-031-14952-8_23
  • Jinit K. Mehta, Meheli A. Banerjee, Priyanka H. Shah, Ginpreet Kaur, and Harpal S. Buttar (2023): Role of Renin Angiotensin System in the Pathophysiology of Coronary Heart Disease: Advancements in Diagnosis, Therapy and Preventive Strategies. In: The Renin Angiotensin System in Cardiovascular Disease. Advances in Biochemistry in Health and Disease 24. Published by Springer. (Editors: Naranjan S. Dhalla Sukhwinder K. Bhullar Anureet K. Shah). Chapter 14, pages 211-235. DOI: https://doi.org/10.1007/978-3-031-14952-8_14
  • Douglas W. Wilson, Paul Nash, Ram B. Singh, Fabien De Meester, Toru Takahashi and Harpal Buttar (2022): International food security directed toward older adults: an overview. In: Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases. Published by Academic Press, an imprint of Elsevier. (Editors: RB Singh, S. Watanabe, AA Isaza), Chapter 41, pages 619 - 640. DOI: https://doi.org/10.1016/B978-0-12-819815-5.00003-3
  • Maushmi S. Kumar, Harpal S. Buttar, Yashodhara Dalal and Ram B. Singh (2022): Cardioprotective and neuroprotective effects of nutraceuticals derived from marine origin. In: Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases. Published by Academic Press, an imprint of Elsevier. (Editors: RB Singh, S. Watanabe, AA Isaza), Chapter 46, pages 707-723. DOI: https://doi.org/10.1016/B978-0-12-819815-5.00003-3
  • Bichitra N. Nayak, Ram B. Singh and Harpal S. Buttar (2022): Biochemical and dietary functions of tryptophan and its metabolites in human health. In: Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases. Published by Academic Press, an imprint of Elsevier. (Editors: RB Singh, S. Watanabe, AA Isaza), Chapter 51, pages 783-798. DOI: https://doi.org/10.1016/B978-0-12-819815-5.00003-3
  • Manju Bhaskar, Istvan G. Telessy, and Harpal S. Buttar (2022): The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-medications and Antidepressants. In: Biomedical Translational Research, Published by Springer Nature Singapore Pte Ltd. [R. C. Sobti, N. S. Dhalla (eds.)], Chapter 15, pages 231-272. https://doi.org/10.1007/978-981-16-9232-1_15
  • Sanit Wichansawakun , Kanokkarn Chupisanyarote , Wannisa Wongpipathpong , Ginpreet Kaur and Harpal S. Buttar (2022): Antioxidant diets and functional foods attenuate dementia and cognition in elderly subjects. In: Functional Foods and Nutraceuticals in Metabolic and Non - communicable Diseases. Published by Academic Press, an imprint of Elsevier. (Editors: RB Singh, S. Watanabe, AA Isaza ), Chapter 37, pages 533 - 549 . DOI: https://doi.org/10.1016/B978 - 0 - 1 2 - 819815 - 5.00003 - 3
  • Mistry A.K., Kaur G., Nagendran S., Buttar H.S. (2021): ANTIOXIDANT AND ANTI-INFLAMMATORY ACTION OF PHYTOBIOACTIVE COMPOUNDS IN CARDIOVASCULAR DISORDERS. In: Bentham Briefs in Biomedicine and Pharmacotherapy: Oxidative Stress and Natural Antioxidants. (Edited by Kaur P, Mehta RG, Robin, Thind TS, Arora S.), Vol.1, Chapter 12, pp. 312-335.
  • Thakkar P., Bagwe-Parab S., Kaur G., Chintamaneni M., Buttar H.S. (2021): THERAPEUTIC POTENTIAL OF PHYTO-CONSTITUENTS FOR THE TREATMENT OF ALZHEIMER’S DISEASE. In: Bentham Briefs in Biomedicine and Pharmacotherapy: Oxidative Stress and Natural Antioxidants. (Edited by Kaur P, Mehta RG, Robin, Thind TS, Arora S.), Vol.1, Chapter 13, pp.336 – 358.

Research interests

  • Reproductive and Developmental Toxicology
  • Risk Assessment of Oral Contraceptives
  • Clinical Nutrition
  • Herbal-drug interactions