Dr. Manoj Lalu

Dr. Manoj Lalu

Profile

Dr. Manoj Lalu
Cross-Appointed Member, Associate Professor, Department of Anesthesiology and Pain Medicine, University of Ottawa, Cross-Appointment to School of Epidemiology and Public Health, University of Ottawa
Lead – Blueprint Translational Research Group
Scientist, Clinical Epidemiology and Regenerative Medicine Programs
OHRI and Associate Professor of Anesthesiology and Pain Medicine

FRCPC – uOttawa, Canada, 2014
MD - University of Alberta, 2008
PhD Pharmacology - University of Alberta, 2004

Room
Department of Anesthesiology and Pain Medicine, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room B309, Ottawa, ON
Phone
(613) 737-8899 ext. 73818


Biography

Research interests

  • Preclinical to clinical (i.e. “bench-to-bedside”) translation (I co-lead the Blueprint Translational Research Group at the Ottawa Hospital Research Institute). We are actively funded by Canadian Institutes of Health Research (CIHR), New Frontiers in Research Fund (NFRF), the Canadian Stem Cell Network, and other national sources.
  • Cell therapy for perioperative medicine and critical illness
  • My group integrates patient partners throughout our research (i.e. “patient engagement”)
  • We are studying and implementing methods to reduce bias and improve rigour in bench/preclinical research
  • We are currently conducting Canada’s first multilaboratory studies
  • Meta-research (e.g. preclinical and clinical systematic reviews)
  • I am also a member of the Centre for Journalology and have a special interest in Predatory Journals

I supervise graduate students in the Cellular and Molecular Medicine Program as well as the School of Epidemiology and Public Health (SEPH). Prospective graduate students, post-doctoral fellows, residents, medical students, and undergraduate students with an interest in the above topics are encouraged to contact me through email ([email protected]).

Honours and awards

  • 2020-2025 – uOttawa Jr Clinical Research Chair in Innovative Translational Research
  • 2022-2024 – Canadian Anesthesiologists’ Society Career Scientist Award
  • 2014 - 2016 - Heart and Stroke Foundation of Canada Research Fellowship

Selected Studies

Multicenter Preclinical Studies, Reducing Bias

  • Hunniford VT, Grudniewicz A, Fergusson DA, Montroy J, Grigor E, Lansdell C, Lalu MM; Canadian Critical Care Translational Biology Group. A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies. Elife. 2023 Mar 9;12:e76300. doi: 10.7554/eLife.76300..
  • Lalu MM, Presseau J, Foster MK, Hunniford VT, Cobey KD, Brehaut JC, Ilkow C, Montroy J, Cardenas A, Sharif A, Jeffers MS, Fergusson DA. Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies. PLoS Biol. 2023 Jan 5;21(1):e3001932. doi: 10.1371/journal.pbio.3001932.
  • Mendelson AA, Lansdell C, Fox-Robichaud AE, Liaw P, Arora J, Cailhier JF, Cepinskas G, Charbonney E, Dos Santos C, Dwivedi D, Ellis CG, Fergusson D, Fiest K, Gill SE, Hendrick K, Hunniford VT, Kowalewska PM, Krewulak K, Lehmann C, Macala K, Marshall JC, Mawdsley L, McDonald B, McDonald E, Medeiros SK, Muniz VS, Osuchowski M, Presseau J, Sharma N, Sohrabipour S, Sunohara-Neilson J, Vázquez-Grande G, Veldhuizen RAW, Welsh D, Winston BW, Zarychanski R, Zhang H, Zhou J, Lalu MM; Sepsis Canada’s National Preclinical Sepsis Platform. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp. 2021 Mar 19;9(1):14
  • Evans JM, Peever A, Grudniewicz A, McDonald B, Mendelson AA, Lalu MM. On the same page? A qualitative study protocol on collaboration in a multi-laboratory preclinical study. PLoS One. 2022 Aug 25;17(8):e0273077. doi: 10.1371/journal.pone.0273077.
  • Zhang M, Macala KF, Fox-Robichaud A, Mendelson AA, Lalu MM; Sepsis Canada National Preclinical Sepsis Platform. Sex- and Gender-Dependent Differences in Clinical and Preclinical Sepsis. Shock. 2021 Jan 4; doi: 10.1097/SHK.0000000000001717
  • McGinn R, Fergusson DA, Stewart DJ, Kristof AS, Barron CC, Thebaud B, McIntyre L, Stacey D, Liepmann M, Dodelet-Devillers A, Zhang H, Renlund R, Lilley E, Downey GP, Brown EG, Côté L, Dos Santos CC, Fox-Robichaud AE, Hussain SNA, Laffey JG, Liu M, MacNeil J, Orlando H, Qureshi ST, Turner PV, Winston BW, Lalu MM; Canadian Critical Care Translational Biology Group. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021 Feb 1;49(2):311-323.

Systematic Reviews (Methodology)

  • Hunniford VT, Montroy J, Fergusson DA, Avey MT, Wever KE, McCann SK, Foster M, Fox G, Lafreniere M, Ghaly M, Mannell S, Godwinska K, Gentles A, Selim S, MacNeil J, Sikora L, Sena ES, Page MJ, Macleod M, Moher D, Lalu MM. Epidemiology and reporting characteristics of preclinical systematic reviews. PLoS Biol. 2021 May 5;19(5):e3001177. doi: 10.1371/journal.pbio.3001177.
  • Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29; 372:n71

Cell Therapy

  • Tieu A, Stewart DJ, Chwastek D, Lansdell C, Burger D, Lalu MM. Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury. Stem Cell Res Ther. 2023 Sep 13;14(1):250. doi: 10.1186/s13287-023-03472-8. PMID: 37705086; PMCID: PMC10500845.
  • Tieu A, Hu K, Gnyra C, Montroy J, Fergusson DA, Allan DS, Stewart DJ, Thébaud B, Lalu MM. Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta-analysis. J Extracell Vesicles. 2021 Oct;10(12):e12141. doi: 10.1002/jev2.12141. PMID: 34596349; PMCID: PMC8485337.
  • Foster M, Fergusson DA, Hunniford V, Cardenas A, Castillo G, Yaworsky J, Mazer CD, Devereaux PJ, McIsaac DI, Stewart DJ, Presseau J, Lalu MM. Understanding potential barriers and enablers to a perioperative early phase cell therapy trial. Cytotherapy. 2022 Jun;24(6):629-638. doi: 10.1016/j.jcyt.2021.08.008. Epub 2022 Apr 6. PMID: 35396169.
  • Lalu MM, Mazzarello S, Zlepnig J, Dong YY, Montroy J, McIntyre L, Devereaux PJ, Stewart DJ, Mazer CD, Barron C, McIsaac DI, Fergusson DA. Safety and efficacy of adult stem cell therapy for acute myocardial infarction and ischemic heart failure – (SafeCell Heart) a systematic review and meta-analysis. Stem Cells Translational Medicine. 7(12):857-866, 2018.

Predatory Journals

  • Lalu MM, Albert MA, Cobey KD. Peering into the dark corners of knowledge synthesis to understand the influence of predatory journals on systematic reviews. J Clin Epidemiol. 2022 Dec;152:295-297. doi: 10.1016/j.jclinepi.2022.09.005.
  • Grudniewicz A, Moher D, Cobey KD, Bryson GL, Cukier S, Allen K, Ardem C, Balcom L, Barros T, Berger M, Ciro JB, Cugusi L, Donaldson MR, Egger M, Graham ID, Hodgkinson M, Khan KM, Mabizela M, Manca A, Milzow K, Mouton J, Muchenje M, Olijhoek T, Ommaya A, Patwardhan B, Poff D, Proulx L, Rodger M, Severin A, Strinzel M, Sylos-Labini M, Tamblyn R, van Niekerk M, Wicherts JM, Lalu MM. Predatory journals: no definition, no defense. Nature. 546(7786): 210-212; 2019.
  • Moher D, Shamseer L, Cobey KD, Lalu MM, Galipeau J, Avey MT, Ahmadzai N, Alabousi M, Barbeau P, Beck A, Daniel R, Frank R, Ghannad M, Hamel C, Hersi M, Hutton B, Isupov I, McGrath TA, McInnes MDF, Page MJ, Pratt M, Pussegoda K, Shea B, Srivastava A, Stevens A, Thavorn K, van Katwyk S, Ward R, Wolfe D, Yazdi F, Yu AM, Ziai H. Stop this waste of people, animals and money. Nature. 549(7670):23-25; 2017
  • Lalu, MM. Shamseer L, Cobey, KD, Moher, D. How stakeholders can respond to predatory journals. Nature Human Behaviour. 1; 852-855; 2017

Patient Engagement

  • Verret M, Fergusson DA, Nicholls SG, Graham M, Zivkovic F, Lê M, Geist A, Lam NH, Graham ID, Turgeon AF, McIsaac DI, Lalu MM. Engaging patients in anesthesiology research: a rewarding frontier. Can J Anaesth. 2023 May;70(5):817-823. doi: 10.1007/s12630-023-02432-3.
  • Fox G, Fergusson DA, Daham Z, Youssef M, Foster M, Poole E, Sharif A, Richards DP, Hendrick K, Mendelson AA, Macala KF, Monfaredi Z, Montroy J, Fiest KM, Presseau J, Lalu MM. Patient engagement in preclinical laboratory research: A scoping review. EBioMedicine. 2021 Jul 16;70:103484. doi: 10.1016/j.ebiom.2021.103484.
  • Foster M, Fergusson DA, Hawrysh T, Presseau J, Kekre N, Schwartz S, Castillo G, Asad S, Fox G, Atkins H, Thavorn K, Montroy J, Holt RA, Mondafaredi Z, Lalu MM. Partnering with patients to get better outcomes with chimeric antigen receptor T-cell therapy: towards engagement of patients in early phase trials. Res Involv Engagem. 6:61; 2020.

Research interests

  • Cell therapy for perioperative medicine and critical illness
  • Patient engagement in clinical and preclinical research
  • Multilaboratory studies, reducing risk of bias and improving reporting in preclinical science
  • Meta-research
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