The Department of Otolaryngology – Head and Neck surgery will perform clinical research that aims to develop health-relate innovations and expand upon our departmental research strengths. As well as expanding intra-departmental collaborations, our research and innovation will maximize synergies with local, national and international partners to produce high quality and transformative research.

Peer-reviewed publications: 2020-current

Khoury M, Azzi JL, Zhang T, Taljaard M, Rourke R, Caulley L, Lelli DA, Tse D.  Exploratory Analysis of Validated Questionnaires for Persistent Postural Perceptual Dizziness.  Submitted for publication to Journal of Vestibular Research 2021.

Azzi JL, Khoury M, Rourke R, Hogan D, Lelli DA, Tse D.  Characteristics of Persistent Postural Perceptual Dizziness Patients in a Multidisciplinary Dizziness Clinic.  Submitted for publication to Journal of Vestibular Research, 2021.

Wasserman J, Rourke R, Purgina B, Caulley L, Dimitroulakos J, Corsten M and Johnson-Obaseki S.  HPV DNA in saliva from patients with SCC of the head and neck is specific for p16-positive oropharyngeal tumours. J Otolaryngol Head Neck Surg. 2017 Jan 6;46(1):3.  doi: 10.1186/s40463-016-0179-6. PMID: 28061890

Koravand, Comeau, Rourke. Music learning for hearing impaired and deaf children: capabilities and effects. Canadian Audiologist. Epub 2020 Vol 7 Issue 5.

Fitzpatrick, McCurdy, Whittingham, Rourke, Nassrallah, Grandpierre, Momoli, Bijelic. Hearing loss prevalence and hearing health among school-aged children in the Canadian Arctic. International Journal of Audiology. Epub 2020 Mar 17.

Hong X, Christ-Franco M, Moher D, Tse D, Lelli DA, Schramm D, Caulley L, Kontorinis G.  Vitamin D Supplementation for Benign Paroxysmal Positional Vertigo: A Systematic Review.  Article in submission Oct 2021

Khoury M, Azzi JL, Zhang T, Taljaard M, Rourke R, Caulley L, Lelli DA, Tse D.  Exploratory Analysis of Validated Questionnaires for Persistent Postural Perceptual Dizziness.  Submitted for publication to Journal of Vestibular Research 2021.

Azzi JL, Khoury M, Rourke R, Hogan D, Lelli DA, Tse D.  Characteristics of Persistent Postural Perceptual Dizziness Patients in a Multidisciplinary Dizziness Clinic.  Submitted for publication to Journal of Vestibular Research, 2021

Bery AK, Azzi JL, Le A, Spitale NS, Leech J, Lelli DA, Tse D.  High Prevalence of Obstructive Sleep Apnea in Cohort of Patients with Persistent Postural Perceptual Dizziness.  Accepted for publication to Journal of Vestibular Research 2021.

Guarnizo A, Farah K, Lelli DA, Tse D, Zakhari N.  Limited Usefulness of Routine Head and Neck CT Angiogram In The Imaging Assessment of Dizziness in the Emergency Department. Neuroradiol J.  2021. Jan 25. E-print ahead of publication.

Grose E, Schramm D, Pigeon M, Vaccani JP The Feasibility of Magnetic Resonance Imaging Without General Anesthesia Using the “Bundle and Scan” Technique for Infants with Sensorineural Hearing Loss. Accepted for publication.  Otology & Neurotology. June 2020

Zalan J, Vaccani JP, Murto KT Pediatric adenotonsillectomy, part 2: considerations for anaesthesia.  BJA Education, 2020 June (6):193-200

Murto KT Zalan J, Vaccani JP Paediatric adenotonsillectomy, part 1: surgical perspectives relevant to the anaesthetist. BJA Education , 2020 April 20(6): 184-192

Alexandra E. Quimby, Debora Hogan, Diana Khalil, Matthew Hearn, Colette Nault and Stephanie Johnson-Obaseki.  Coconut Oil as a Novel Approach to Managing Radiation-Induced Xerostomia: A Primary Feasibility Study. International Journal of Otolaryngology Sept 2020, https://doi.org/10.1155/2020/8537643

Heidi Oi-Yee Li, Adrian Bailey, Elysia Grose, James Ted McDonald, Alexandra Quimby, Stephanie Johnson-Obaseki, Carolyn Nessim.  Socioeconomic status and melanoma in Canada: A systematic review.  Accepted to the Journal of Cutaneous Medicine and Surgery Aug 2020.

Caulley L, Corsten M, Eapen L, Whelan J, Angel JB, Antonation K, Bastien N, Poliquin G, Johnson-Obaseki S. Salivary Detection of COVID-19. Ann Intern Med. Aug 2020. doi: 10.7326/M20-4738. Online ahead of print. PMID: 32857591

Quality indicators of central compartment neck dissection in thyroid surgery.  Quimby A, Corsten MJ, Grose E, Odell M and Johnson-Obaseki S.   Accepted to Journal of Otolaryngology-Head Neck Surgery Apr 2020.

Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial.  Nichols AC, Lang P, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Fung K, de Almeida JR, Bayley A, Goldstein DP, Eskander A, Husain Z, Bahig H, Christopoulous A, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Mendez A, Winquist E, Read N, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Corsten M, Rajaraman M, Johnson-Obaseki S et al.  BMC Cancer. 2020 Feb 14;20(1):125. doi: 10.1186/s12885-020-6607-z.  PMID: 32059705 Free PMC article.

Lebo N, Quimby A, Caulley L, Thavorn K, Kekre N, Brode S and Johnson-Obaseki S. Laryngoscope 2020 Jan 24. doi: 10.1002/lary.28512.

L. Caulley, J. Shaw, M. Corsten, N. Hua, J. Angel, G. Poliquin, J. Whelan, K. Antonation, N. Bastien, S. Johnson-Obaseki. Salivary testing of COVID-19: Evaluation of serological testing following positive salivary results. Submitted to BMC Infectious Diseases. Feb 2021

M. Alahmari, F. Alkherayf, A. Lasso, F. Banaz, S. Mohajeri, P. Masoudian, A. Lamothe, C. Agbi, L. Caulley, M. Alshardan, S. Kilty. Recovery of Cranial Nerve Deficits in Patients Presenting with Pituitary Apoplexy: A Case Series. Journal of Neurological Surgery, Part B. 2021 Jan

X. Hong*, M. Christ-Franco*, D. Moher, D. Tse, D. Lelli, D. Schramm, L. Caulley^, G. Kontorinis^. Vitamin D Supplementation for Benign Paroxysmal Positional Vertigo: A Systematic Review. Submitted to JAMA Otolaryngology-Head and Neck Surgery. Jan 2021

L. Caulley^, M. Sawada^, E. Crighton, M. Khoury, G. Kontorinis. Association between socioeconomic indicators and geographic distribution of vestibular schwannomas in West Scotland: A 15 Year Review. Journal of Laryngology & Otology. 2020 Dec 3

L. Caulley, J. James, C. Hopkins. Use of Non-Medicated Control Substances on Chronic Rhinosinusitis: A Single-Arm Systematic Review and Meta-Analysis. JAMA Otolaryngology-Head and Neck Surgery. 2020 Nov 12

M. Khoury, J. Lee Azzi, T. Zhang, M. Taljaard, R. Rourke, L. Caulley, D. A. Lelli, D. Tse. The Use of Validated Questionnaires to Facilitate Diagnosis of Persistent Postural Perceptual Dizziness. Submitted to Journal of Vestibular Research. October 2020

L. Caulley, M. Corsten, L. Eapen, J. Whelan, K. Antonation, N. Bastien, J. Angel, G. Poliquin,  S. Johnson-Obaseki. Salivary Detection of COVID-19. Annals of Internal Medicine. 2020 Aug 28

M. Khoury, H. Alsaffar, S. Johnson-Obaseki, L. Caulley. Isolated Oropharyngeal Abscess with Hypopharyngeal Extension Recurring 12 Years After Initial Surgical Management: A Case Report. Journal of Medical Case Reports. Submitted August 2020

L. Caulley, M. Hunink, J. Shin. Evidence-Based Medicine in Otolaryngology, Part XI: Modeling and Analysis to Support Decisions. Otolaryngology-Head and Neck Surgery. 2020 Aug 25

L. Caulley, W. Cheng, F. Catalá-López, J. Whelan, M.Khoury, J. Ferraro, D. Husereau, D. Altman, D.Moher, Citation Impact of Reporting Guidelines for Health Research. Journal of Clinical Epidemiology. 2020 Jul 23

J. James*, L. Caulley, J. Collins, C. Hopkins. Complications of Intranasal Corticosteroids in Patients with HIV. Submitted to BMJ Case Reports. July 2020

L. Caulley, A. Takhar, F. Bast, P. Surda, C. Hopkins. Non-Disclosure of Cocaine Use in the Rhinology Practice: A Retrospective Study of 27 Patients. Clinical Otolaryngology. 2020 Apr 3

L. Caulley, J. Quinn, M. Doyle, F. Alkherayf, S. Kilty, M. Hunink. Clinical Efficacy of Surgical and Non-Surgical Interventions in the Management of Growth Hormone Secreting Pituitary Adenomas (Protocol). Cochrane Database of Systematic Reviews. 2020 Mar 19

L. Caulley, W. Cheng, F. Catalá-López, J. Whelan, M. Khoury, J. Ferraro, D. Husereau, D. Altman, D.Moher. Reporting guidelines of health research studies are frequently used inappropriately. Journal of Clinical Epidemiology. 2020 Mar 14

L. Caulley, R. Uppaluri, I. Dunn. Perioperative Nasal and Paranasal Sinus Considerations in Transsphenoidal Surgery for Pituitary Disease. British Journal ofNeurosurgery. 2020 Feb 25

W. Fokkens, V. Lund, C. Hopkins, P. Hellings et al on behalf of the European Rhinologic Society. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020 Feb 20

F. Catalá-López, L. Caulley, M. Ridao, B. Hutton, D. Husereau, M. Drummond, A. Alonso-Arroyo, M. Pardo-Fernández, E. Bernal-Delgado, R. Meneu, R. Tabarés-Seisdedos, J. Repullo, D. Moher. Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis. BMJ Open. 2020 Feb 13

F. Catalá-López, R. Alexandre-Benavent, L. Caulley, B. Hutton, R.Tabarés-Seisdedos, D. Moher, A. Alonso-Arroyo. Global Mapping of Randomised Trials Related Articles Published in High-Impact Factor Medical Journals: A Cross-Sectional Analysis. Trials. 2020 Jan 7

N. Lebo, A. Quimby, L. Caulley, K. Thavorn, N. Kekre, S. Brode, S. Johnson-Obaseki. Surgical site infection affects length of stay and cost after complex head and neck procedures. The Larygnoscope. 2020 Jan 24

Han JK, Bachert C, Fokkens W, Desrosiers M, Wagenmann M, Lee SE, Smith SG, Martin N, Mayer B, Yancey SW, Sousa AR, Chan R, Hopkins C; SYNAPSE study investigators. Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2021 Apr 16: S2213-2600(21)00097-7. doi: 10.1016/S2213-2600(21)00097-7. Epub ahead of print. PMID: 33872587

Thamboo A, Kilty S, Witterick I, Chan Y, Chin CJ, Janjua A, Javer A, Lee J, Monterio E, Rotenberg B, Scott J, Smith K, Sommer DD, Sowerby L, Tewfik M, Wright E, Desrosiers M. Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis. J Otolaryngol Head Neck Surg. 2021 Mar 9;50(1):15. doi: 10.1186/s40463-021-00493-2. PMID: 33750471; PMCID: PMC7945300

Alahmari M; Alkherayf F; Lasso A; Banaz F; Mohajeri S; Masoudian P; Lamothe A; Agbi C; Caulley L; Alshardan M; Kilty S.  (2021). Recovery of Cranial Nerve Deficits in Patients Presenting with Pituitary Apoplexy: A Case Series. J Neurol Surg B Skull Base DOI: 10.1055/s-0040-1722668

Kilty S, Thavorn K, Janjua A, Lee J, MacDonald K, Meen E, Micomonaco D, Rotenberg B, Sowerby LJ, Tewfik M, Adams S, Frenette H, Lasso A, Fergusson DA. Endoscopic polypectomy performed in clinic for chronic rhinosinusitis with nasal polyps: study protocol for the EPIC multicentre randomised controlled trial. BMJ Open. 2020 Dec 2;10(12):e042413. doi: 10.1136/bmjopen-2020-042413. PMID: 33268434; PMCID: PMC7713191.

Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Hutton B. Pharmacologic and surgical therapies for patients with Meniere's disease: A systematic review and network meta-analysis. PLoS One. 2020 Sep 1;15(9):e0237523. doi: 10.1371/journal.pone.0237523. PMID: 32870918; PMCID: PMC7462264.

Kumar S, Thavorn K, van Katwyk S, Lasso A, Kilty SJ. Cost-effectiveness of Endoscopic Polypectomy in Clinic compared to Endoscopic Sinus Surgery: A modelling study. Clin Otolaryngol. 2020 Jul;45(4):477-485. doi: 10.1111/coa.13533. Epub 2020 Apr 26. PMID: 32227591.

Cottrell J, Yip J, Chan Y, Chin CJ, Damji A, de Almeida JR, Desrosiers M, Eskander A, Janjua A, Kilty S, Lee JM, Macdonald KI, Meen EK, Rudmik L, Sommer DD, Sowerby L, Tewfik MA, Thamboo A, Vescan AD, Witterick IJ, Wright E, Monteiro E. Quality Indicators for the Diagnosis and Management of Acute Bacterial Rhinosinusitis. Am J Rhinol Allergy. 2020 Jul;34(4):519-531. doi: 10.1177/1945892420912158. Epub 2020 Mar 24. PMID: 32208748.

Arnstead N, Chan Y, Kilty S, Ganeshathasan R, Rahmani A, Monteiro E; Rhinology Subspecialty Group of the Canadian Society of Otolaryngology – Head & Neck Surgery. Choosing Wisely Canada rhinology recommendations. J Otolaryngol Head Neck Surg. 2020 Feb 28;49(1):10. doi: 10.1186/s40463-020-00406-9. PMID: 32111259; PMCID: PMC7049188.

Data-Driven Audiogram Classification for Mobile Audiometry. Charih F, Bromwich M, Mark AE, Lefrançois R, Green JR.Sci Rep. 2020 Mar 3;10(1):3962. doi: 10.1038/s41598-020-60898-3.PMID: 32127604 Free PMC article.

Predictors of postoperative respiratory complications in children undergoing adenotonsillectomy. Katz SL, Monsour A, Barrowman N, Hoey L, Bromwich M, Momoli F, Chan T, Goldberg R, Patel A, Yin L, Murto K.J Clin Sleep Med. 2020 Jan 15;16(1):41-48. doi: 10.5664/jcsm.8118. Epub 2019 Nov 27.PMID: 31957650 Free PMC article.

McLean, L.  IFOS 2021:  Imagining Inspirational Continuing Professional Development.  ENT and Audiology News.  September-October 2020.  Volume 29, No 4, p 41-3.  www.entaudiologynews.com

Fitzpatrick E, Carrier V, Turgeon G, Olmstead T, McAfee A, Whittingham J, Schramm D. (2020) Benefits of Auditory-Verbal Intervention for Adult Cochlear Implant Users: Perspectives of Users and their Coaches. Revised manuscript submitted to International Journal of Audiology December 2, 2020

Chen J, Fitzpatrick E, Na E, Little J, Sikora L, Yang J, Schramm D. Telepractice (2020) Auditory-verbal therapy for promoting speech and language development in children with cochlear implant: A systematic review. Ear and Hearing Accepted October 13, 2020 subject to minor revisions

Sedra S, Mallick R, Nayak AL, Choudhry AJ, Bougie O, Singh SS, Arendas K, Saidenberg E, Schramm DR, Chen I. Venous Thromboembolism After Blood Transfusions in Women Undergoing Hysterectomy for Non-Malignant Indications: A Retrospective Cohort Study. J Obstet Gynaecol Can. 2021 Feb;43(2):167-174. doi: 10.1016/j.jogc.2020.09.016. Epub 2020 Sep 30. PMID: 33229282

Alkherayf F, Kheshaifati H, Algahtani A, Chakraborty S, Schramm D. (2020) Superior semicircular canal dehiscence syndrome. Journal of Otolaryngology and Ophthalmology of Shandong University October ISSN 1673-3770. CN 37-1437/R https://kns.cnki.net/kcms/detail/37.1437.R.20200925.1802.005.html

Schramm D, Chen J, Morris DP, Shoman N, Philippon D, Cayé-Thomasen P, Hoen M, Karoui C, Laplante-Lévesque A, Gnansia D. Clinical Efficiency and Safety of the Oticon Medical Neuro Cochlear Implant System: A Multicenter Prospective Longitudinal Study. Expert Rev Med Devices. 2020 Sep 4. doi: 10.1080/17434440.2020.1814741. Epub ahead of print. PMID: 32885711.

Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Hutton B. (2020) Pharmacologic and surgical therapies for patients with Meniere's disease: A systematic review and network meta-analysis. PLoS One. 2020 Sep 1;15(9):e0237523. Doi: 10.1371/journal.pone.0237523. PMID: 32870918; PMCID: PMC7462264.

Grose E, Pigeon M, Abdeen N, Belanger M, Schramm D, Vaccani JP. (2020) The Feasibility of Magnetic Resonance Imaging Without General Anesthesia Using the "Bundle and Scan" Technique for Infants With Sensorineural Hearing Loss. Otol Neurotol. Aug 17. doi: 10.1097/MAO.0000000000002838. Epub ahead of print. PMID: 32810007.