Dr. Pelling is generally interested in understanding the dynamic mechanical properties of cellular systems across nanometer and micrometer length scales. The mechanical response and transduction pathways of living cells are explored using genetic manipulation and a variety of scanning probe and optical techniques. The long term goals of his research program are to understand the genetic and architectural control mechanisms of mechanotransduction pathways in health and disease.
Selected publications
- Pelling, A.E., Veraitch, F.S., Chu, C.P.K., Mason, C., Horton, M.A. Mechanical dynamics of single cells during early apoptosis. Cell Motil. Cytoskeleton 66, 409, 2009
- Hogan, C., Dupre-Crochet, S., Norman, M., Kajita, M., Zimmermann, C., Pelling, A.E., Piddini, E., Baena-Lopez, A., Vincent, J., Itoh, Y., Hosoya, H., Pichaud, F., Fujita, Y. Characterization of the interface between normal and transformed epithelial cells. Nat. Cell Biol. 11, 460, 2009
- Kunda, P., Pelling, A.E., Liu, T., Baum, B. Moesin controls cortical rigidity, cell rounding and spindle assembly during mitosis. Curr. Biol. 18, 91, 2008
- Pelling, A.E., Li, Y., Shi, W., Gimzewski, J.K. Nanoscale visualization and characterization of Myxococcus xanthus cells with atomic force microscopy. Proc. Natl. Acad. Sci. USA. 102, 6484, 2005
- Pelling, A.E., Sehati, S., Gralla, E.B., Valentine, J.S., Gimzewski, J.K. Local nanomechanical motion of the cell wall of Saccharomyces cerevisiae. Science 304, 1147, 2004