François-Xavier Campbell-Valois

The Host-Microbe Interaction lab is interested in understanding the interplay established between bacteria and their host during infection. We are currently focusing on the enteropathogen Shigella flexneri, which use a Type Three Secretion Apparatus (T3SA) to inject some of its proteins inside human intestinal cells. Our main interests are: 1) T3SA functioning and regulation; 2) bacterial strategies for hijacking the biological processes of the host; 3) bacterial and host adaptation at play during infection. Our long-term objective is to identify novel therapeutic avenues to treat infectious diseases.

• Manigat FO, Connell LB, Stewart BN, LePabic AR, Tessier CJG, Emlaw JR, Calvert ND, Rössl A, Shuhendler AJ, daCosta CJB, Campbell-Valois FX. pUdOs: Concise Plasmids for Bacterial and Mammalian Cells. ACS Synth Biol. 2024 Feb 16;13(2):485-497. 
• Tchagang CF, Mah TF, Campbell-Valois FX. Anaerobic fluorescent reporters for live imaging of Pseudomonas aeruginosa. Front Microbiol. 2023 Oct 20;14:1245755. 
• Haidar-Ahmad N, Manigat FO, Silué N, Pontier SM, Campbell-Valois FX. A Tale about Shigella: Evolution, Plasmid, and Virulence. Microorganisms. 2023 Jun 30;11(7):1709. 
• Silué N, Campbell-Valois FX. icaR and icaT are Ancient Chromosome Genes Encoding Substrates of the Type III Secretion Apparatus in Shigella flexneri. mSphere. 2022 Jun 29;7(3):e0011522.
• Bajunaid W, Haidar-Ahmad N, Kottarampatel AH, Ourida Manigat F, Silué N, Tchagang CF, Tomaro K, Campbell-Valois FX. The T3SS of Shigella: Expression, Structure, Function, and Role in Vacuole Escape. Microorganisms. 2020 Dec 5;8(12):1933.
• Campbell-Valois FX, Schnupf P, Nigro G, Sachse M, Sansonetti PJ, Parsot C. A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread. Cell Host Microbe. 2014 Feb 12;15(2):177-89. 

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