Mechanistic interaction between brain-heart and early detection innovations
• Cardiovascular links to neurodegenerative diseases with a focus on cognitive health & dementia, microvasculature mechanisms underlying neurodegeneration and/or neurodevelopment.
• Mechanistic interactions between the brain and the heart through the lens of neuroimmunology or mental health, for example.
• Technology innovation for the early detection of heart and brain conditions through biomarker discovery, predictive modeling, and novel screening tools.
• Advancing mental health research with a focus on the role of youth mental health as a predictor of cardiovascular disease later in life and engaging expertise from psychiatry and psychology.
• Addressing modifiable risk factors including social determinants of health and interpersonal and behavioural factors that influence interconnected brain-heart health outcomes.
Health Policy and Health System Innovation
• Health, economic and/or social policies at the local, provincial, national and/or international level to accelerate the advancement of brain-heart technologies or improve health and quality of live for people living with or at risk of interconnected brain-heart conditions.
• Innovations in health or social systems and programs to address priorities of communities, governments and other service providers and the spread and scale-up of these innovations.
Big Data and Artificial Intelligence
• Computational neuroscience and neuro-AI to model and predict the evolution of brain-heart conditions.
• Identifying, assessing and addressing modifiable risk factors for brain-heart conditions, including social-determinants of health, using big data analysis.
• Analysis and integration of genomics, proteomics and multi-omics data.