The vision of BHI is to provide long-term, sustainable global leadership in integrated B-H research to reduce the world-wide burden of disease. As a mission-driven research and knowledge mobilization platform, the BHI model is built on two main research foundations: Clinical/Epidemiology, and Basic Science/Discovery, and incorporates four research priorities: Therapeutics; Biomarkers and Imaging Tools; Precision Prevention across the Life Trajectory; and Health Systems and Models of Care. It uses a life trajectory approach and looks to take innovations from bench to bedside and back.