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Solving a key supply chain issue using continuous manufacturing

Partnering with a Canadian fine chemical manufacturing specialist, the uOttawa team pioneered a safe and agile process for the synthesis of a key diagnostic ingredient for SARS-COV-2.

Overview

Performing reduction chemistry using lithium aluminum hydride always requires caution. Conducting the same under a flow condition adds more to that challenge. From moving a thick slurry of the highly reactive hydride reagent to taming possible thermal runaway conditions, the hazard and the risk remained the primary concern. But Prof. Michael Organ of the University of Ottawa saw the benefits buried deep beneath obvious engineering challenges. Partnering with a Canadian fine chemical manufacturing specialist, the uOttawa team pioneered a safe and agile process for the synthesis of a key diagnostic ingredient for SARS-COV-2. It's a perfect way to demonstrate how academia can give back to society a commodity essential towards fighting a global pandemic.

To learn more about the scientific work and the media release, please follow links below:

Lithium aluminum hydride
Lithium aluminum hydride in flow
Lithium aluminum hydride

The article

Lithium aluminum hydride in flow: overcoming exotherms, solids, and gas evolution en route to chemoselective reductions.
CCRI news
flow chemistry lab
CCRI news

The media release

A little goes a long way: uOttawa research team plays key role in global detection of COVID-19